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J Nat Prod. 2013 Apr 26;76(4):779-82. doi: 10.1021/np4002042. Epub 2013 Apr 15.

Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus.

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1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

Abstract

Fumiquinazoline L (1), an alkaloid with a heptacyclic skeleton formed via a bridging hemiaminal linkage, was isolated from a gorgonian-derived Scopulariopsis sp. fungus. The structure and absolute configuration of the new compound were identified by comprehensive spectroscopic data and X-ray diffraction analysis. During acid hydrolysis of 1, the isomerization of the valine residue was observed and also studied in different conditions. Fumiquinazoline L (1) showed no cytotoxic or antibacterial activities.

PMID:
23586849
DOI:
10.1021/np4002042
[Indexed for MEDLINE]
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