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Chem Commun (Camb). 2013 May 25;49(42):4758-60. doi: 10.1039/c3cc40868j.

A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex.

Author information

1
Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.

Abstract

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

PMID:
23586078
DOI:
10.1039/c3cc40868j
[Indexed for MEDLINE]

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