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J Thorac Dis. 2013 Apr;5(2):E65-7. doi: 10.3978/j.issn.2072-1439.2012.12.09.

Complete response of 7 years' duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma.

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  • 1Department of Chest Surgery, Toho University Omori Medical Center, Tokyo, Japan;

Abstract

Intramedullary spinal cord metastasis is a rare but serious complication which causes rapid progression of neurological deficits. Here we report a 35-year-old man presenting with increasing leg pain and gait disturbance, 8 months after surgery for lung adenocarcinoma. Spinal magnetic resonance imaging revealed an intramedullary tumor at the Th7/8 level. Radiotherapy at 35 Gy resulted in transient symptomatic improvement, but during chemotherapy with vinorelbine and cisplatin, symptoms worsened again. Gefitinib was then administered; the patient improved after 2 weeks and has now maintained a complete response for 7 years.

KEYWORDS:

EGFR; Intramedullary spinal cord metastasis; gefitinib; lung cancer; magnetic resonance imaging; positron-emission tomography

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