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J Infect Dis. 2013 Jul 15;208(2):192-8. doi: 10.1093/infdis/jit116. Epub 2013 Apr 12.

Lethal malaria: Marchiafava and Bignami were right.

Author information

1
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac

Abstract

One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.

KEYWORDS:

P. falciparum; cerebral malaria; malaria; pathology

PMID:
23585685
PMCID:
PMC3685223
DOI:
10.1093/infdis/jit116
[Indexed for MEDLINE]
Free PMC Article

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