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Food Chem Toxicol. 2013 Jul;57:362-70. doi: 10.1016/j.fct.2013.04.001. Epub 2013 Apr 9.

Molecular mechanisms for the anti-cancer effects of diallyl disulfide.

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1
Cancer Research Institute, University of South China, Hengyang 421001, Hunan Province, China.

Abstract

Considerable evidence in recent years suggests that garlic has anti-proliferative effects against various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than water-soluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can decrease carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. Its mechanisms of action include: the activation of metabolizing enzymes that detoxify carcinogens; suppression of the formation of DNA adducts; antioxidant effects; regulation of cell-cycle arrest; induction of apoptosis and differentiation; histone modification; and inhibition of angiogenesis and invasion. These topics are discussed in depth in this review.

PMID:
23583486
DOI:
10.1016/j.fct.2013.04.001
[Indexed for MEDLINE]

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