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Biochem Pharmacol. 2013 Jul 1;86(1):56-66. doi: 10.1016/j.bcp.2013.03.021. Epub 2013 Apr 10.

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.

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1
Division of Pathway Medicine, University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh EH16 4SB, Scotland, UK. a.mazein@oist.jp

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

PMID:
23583456
PMCID:
PMC3912678
DOI:
10.1016/j.bcp.2013.03.021
[Indexed for MEDLINE]
Free PMC Article
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