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Fitoterapia. 2013 Jul;88:25-30. doi: 10.1016/j.fitote.2013.04.003. Epub 2013 Apr 12.

Two new steroidal saponins from Selaginella uncinata (Desv.) Spring and their protective effect against anoxia.

Author information

  • 1Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, PR China. Electronic address:
  • 2Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, PR China.
  • 3School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
  • 4Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, PR China.
  • 5Key Lab for Research & Development of New Drugs, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, PR China.
  • 6Institute of Basic Medical Sciences, Beijing 100850, PR China.


Four steroidal saponins were isolated from the anti-anoxic fraction of the 60% EtOH extract of Selaginella uncinata, including two new compounds, (3β, 7β, 12β, 25R)-spirost-5-ene-3, 7, 12-triol-3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-O-β-D-glucopyranoside (1), (2α, 3β, 12β, 25R)-spirost-5-ene-2, 3, 12-triol-3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-O-β-D-glucopyranoside (2) and two known compounds, (3β, 12β, 25R)-spirost-5-ene-3,12-diol-3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-O-β-D-glucopyranoside, (3), (1α, 3β, 25R)-spirost-5-ene-2-diol-3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl(1→4)]-O-β-D-glucopyranoside (4). The four compounds showed potent protective effect against anoxia in the anoxic PC12 cells assay, among which compounds 1 and 2 were the most active. To our knowledge, this is the first study to report the steroidal saponins in the plant S. uncinata and demonstrate their protective effect against anoxia in PC12 cell assay.

Copyright © 2013 Elsevier B.V. All rights reserved.


Protective effect against anoxia; Selaginella uncinata; Steroidal saponins

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