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Exp Neurol. 2013 Jun;244:87-95. doi: 10.1016/j.expneurol.2013.04.004. Epub 2013 Apr 11.

Neurostimulation in the treatment of epilepsy.

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Department of Neurology, Johns Hopkins Hospital, Meyer 2-147, 600 North Wolfe Street, Baltimore, MD 21287, USA.


There is increased interest in neurostimulation as a treatment for drug-resistant epilepsy. Two large pivotal trials have recently been completed, one using bilateral anterior thalamic stimulation and another employing closed loop responsive therapy of the brain. These are potential additions to the therapeutic options for neurostimulation in addition to already approved vagus nerve stimulation. This review will address the principles of the various types of neurostimulation, the results of the pivotal trials and the important considerations for interpreting the results of these trials which differ from trials of antiepileptic drugs.

[Indexed for MEDLINE]

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