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Alzheimers Dement. 2014 Jan;10(1):e1-8. doi: 10.1016/j.jalz.2013.01.009. Epub 2013 Apr 11.

Fibrillar amyloid correlates of preclinical cognitive decline.

Author information

1
Department of Psychiatry & Psychology, Mayo Clinic in Arizona, Scottsdale, AZ, USA. Electronic address: stonnington.cynthia@mayo.edu.
2
Banner Alzheimer's Institute, Phoenix, AZ, USA.
3
Department of Psychiatry & Psychology, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
4
Department of Biostatistics, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
5
Banner Alzheimer's Institute, Phoenix, AZ, USA; Department of Neurosciences, University of California-San Diego, San Diego, CA, USA.
6
Department of Neurology, Mayo Clinic in Arizona, Scottsdale, AZ, USA.

Abstract

BACKGROUND:

It is not known whether preclinical cognitive decline is associated with fibrillar β-amyloid (Aβ) deposition irrespective of apolipoprotein E (APOE) ε4 status.

METHODS:

From a prospective observational study of 623 cognitively normal individuals, we identified all subjects who showed preclinical decline of at least 2 standard deviations beyond the decline of the entire group in memory or executive function. Fourteen decliners were matched by APOE ε4 gene dose, age, sex, and education with 14 nondecliners. Dynamic Pittsburgh compound B (PiB) positron emission tomography (PET) scans, the Logan method, statistical parametric mapping, and automatically labeled regions of interest were used to characterize and compare cerebral-to-cerebellar PiB distribution volume ratios (DVRs), reflecting fibrillar Aβ burden.

RESULTS:

At P < .005 (uncorrected), decliners had significantly greater DVRs in comparison to nondecliners.

CONCLUSIONS:

Asymptomatic longitudinal neuropsychological decline is associated with subsequent increased fibrillar amyloid deposition, even when controlling for APOE ε4 genotype.

KEYWORDS:

Alzheimer's disease; Amyloid imaging; Apolipoprotein E; Cognitive decline; Preclinical

PMID:
23583233
PMCID:
PMC3713087
DOI:
10.1016/j.jalz.2013.01.009
[Indexed for MEDLINE]
Free PMC Article
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