Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2013 Apr 11;153(2):376-88. doi: 10.1016/j.cell.2013.02.053.

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

Author information

1
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.

Abstract

In vertebrates, activation of innate immunity is an early response to injury, implicating it in the regenerative process. However, the mechanisms by which innate signals might regulate stem cell functionality are unknown. Here, we demonstrate that type 2 innate immunity is required for regeneration of skeletal muscle after injury. Muscle damage results in rapid recruitment of eosinophils, which secrete IL-4 to activate the regenerative actions of muscle resident fibro/adipocyte progenitors (FAPs). In FAPs, IL-4/IL-13 signaling serves as a key switch to control their fate and functions. Activation of IL-4/IL-13 signaling promotes proliferation of FAPs to support myogenesis while inhibiting their differentiation into adipocytes. Surprisingly, type 2 cytokine signaling is also required in FAPs, but not in myeloid cells, for rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues.

PMID:
23582327
PMCID:
PMC3663598
DOI:
10.1016/j.cell.2013.02.053
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center