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Cell. 2013 Apr 11;153(2):293-305. doi: 10.1016/j.cell.2013.03.034.

Allostery in disease and in drug discovery.

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1
National Cancer Institute, Center for Cancer Research Nanobiology Program, Frederick National Laboratory for Cancer Research, SAIC-Frederick, Inc., National Cancer Institute, Frederick, MD 21702, USA. nussinor@helix.nih.gov

Abstract

Allostery is largely associated with conformational and functional transitions in individual proteins. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. Here, we clarify the concept of allostery and how it controls physiological activities. We focus on the challenging questions of how allostery can both cause disease and contribute to development of new therapeutics. We aim to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level and to emphasize the potential of allosteric drugs in innovative therapies.

PMID:
23582321
DOI:
10.1016/j.cell.2013.03.034
[Indexed for MEDLINE]
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