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Cell. 2013 Apr 11;153(2):287-92. doi: 10.1016/j.cell.2013.03.013.

Higher-order assemblies in a new paradigm of signal transduction.

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1
Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. hao.wu@childrens.harvard.edu

Abstract

Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.

PMID:
23582320
PMCID:
PMC3687143
DOI:
10.1016/j.cell.2013.03.013
[Indexed for MEDLINE]
Free PMC Article
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