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Mol Cell. 2013 Apr 11;50(1):2-4. doi: 10.1016/j.molcel.2013.03.025.

Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control.

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Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.


In this issue of Molecular Cell, Jiao et al. (2013) describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping, and 5'-3' exoribonuclease activity and functions as an important checkpoint in cotranscriptional capping of RNA polymerase II (Pol II) pre-mRNA transcripts.

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