Format

Send to

Choose Destination
ACS Chem Neurosci. 2013 May 15;4(5):693-703. doi: 10.1021/cn400026v. Epub 2013 May 6.

Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices.

Author information

1
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, United States.

Abstract

Fast scan cyclic voltammetry in brain slices (slice voltammetry) has been used over the last several decades to increase substantially our understanding of the complex local regulation of dopamine release and uptake in the striatum. This technique is routinely used for the study of changes that occur in the dopamine system associated with various disease states and pharmacological treatments, and to study mechanisms of local circuitry regulation of dopamine terminal function. In the context of this Review, we compare the relative advantages of voltammetry using striatal slice preparations versus in vivo preparations, and highlight recent advances in our understanding of dopamine release and uptake in the striatum specifically from studies that use slice voltammetry in drug-naïve animals and animals with a history of psychostimulant self-administration.

PMID:
23581570
PMCID:
PMC3656744
DOI:
10.1021/cn400026v
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center