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J Matern Fetal Neonatal Med. 2013 Nov;26(16):1667-70. doi: 10.3109/14767058.2013.795536. Epub 2013 May 9.

Effectiveness of strict anti-contamination criteria for non-invasive foetal sex determination in a clinical setting.

Author information

1
Andros Day Surgery, Molecular Biology Unit , Palermo , Italy and.

Abstract

OBJECTIVE:

The aim of this study is to prevent false positive results in non-invasive foetal sex determination from pregnant women's plasma following strict anti-contamination criteria.

METHODS:

cffDNA from 200 pregnant women (mean gestational age of 8.3 ± 0.2 weeks) was analyzed based on genetic forensic anti-contamination procedures and classical non-invasive foetal sex determination techniques.

RESULTS:

No false positive or false negative was reported. The sensitivity and the specificity reached both a 100% value.

CONCLUSIONS:

Prevention of contamination following our anti-contamination criteria is a good practice for certain non-invasive sex determination, using cffDNA.

PMID:
23581568
DOI:
10.3109/14767058.2013.795536
[Indexed for MEDLINE]

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