Format

Send to

Choose Destination
Front Med. 2013 Jun;7(2):207-22. doi: 10.1007/s11684-013-0263-5. Epub 2013 Apr 12.

Leptin signaling and leptin resistance.

Author information

1
Cambridge Laboratories, Pfizer Worldwide Research & Development, Cambridge, MA 02139, USA. ayingjiang.zhou@pfizer.com

Abstract

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain, particularly in the hypothalamus. These LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus, forming a neural network that controls the energy homeostasis and body weight. Multiple factors, including inflammation and endoplasmic reticulum (ER) stress, contribute to leptin resistance. Leptin resistance is the key risk factor for obesity. This review is focused on recent advance about leptin action, leptin signaling, and leptin resistance.

PMID:
23580174
PMCID:
PMC4069066
DOI:
10.1007/s11684-013-0263-5
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center