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Trends Cogn Sci. 2013 May;17(5):241-54. doi: 10.1016/j.tics.2013.03.003. Epub 2013 Apr 9.

Cerebellar networks with the cerebral cortex and basal ganglia.

Author information

1
Center for the Neural Basis of Cognition, Systems Neuroscience Institute and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Abstract

The dominant view of cerebellar function has been that it is exclusively concerned with motor control and coordination. Recent findings from neuroanatomical, behavioral, and imaging studies have profoundly changed this view. Neuroanatomical studies using virus transneuronal tracers have demonstrated that cerebellar output reaches vast areas of the neocortex, including regions of prefrontal and posterior parietal cortex. Furthermore, it has recently become clear that the cerebellum is reciprocally connected with the basal ganglia, which suggests that the two subcortical structures are part of a densely interconnected network. Taken together, these findings elucidate the neuroanatomical substrate for cerebellar involvement in non-motor functions mediated by the prefrontal and posterior parietal cortex, as well as in processes traditionally associated with the basal ganglia.

PMID:
23579055
PMCID:
PMC3645327
DOI:
10.1016/j.tics.2013.03.003
[Indexed for MEDLINE]
Free PMC Article

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