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Biotechnol Adv. 2013 Nov;31(6):811-7. doi: 10.1016/j.biotechadv.2013.03.012. Epub 2013 Apr 8.

Synthetic biology: tools to design microbes for the production of chemicals and fuels.

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Department of Chemical Engineering, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam-gu, Pohang, Gyeongbuk 790-784, Republic of Korea.


The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. In this paper, we review current developments in the design of tools for controlling gene expression at transcriptional, post-transcriptional and post-translational levels, and consider potential applications of these tools.


Biochemical; Biofuel; Expression control; Metabolic engineering; Microbial cell factory; Synthetic biology

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