Curr Biol. 2013 Apr 8;23(7):R276-8. doi: 10.1016/j.cub.2013.02.040.

Quantitative genetics: heritability is not always missing.

Author information

1: Centre for Genetics and Genomics, School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. John.Brookfield@nottingham.ac.uk

Abstract

Quantitative trait loci (QTLs) underlying multifactorial disorders explain little of the heritability - most is 'missing'. A new yeast study has identified QTLs which explain most heritability in traits. Why is heritability missing in human diseases but not here?

PMID:: 23578874
DOI:: 10.1016/j.cub.2013.02.040

[Indexed for MEDLINE]

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MeSH terms

Genetic Predisposition to Disease/genetics*
Genome-Wide Association Study/methods
Genome-Wide Association Study/trends*
Humans
Inheritance Patterns/genetics*
Models, Genetic
Quantitative Trait Loci/genetics*
Yeasts

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Quantitative genetics: heritability is not always missing.

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