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Curr Biol. 2013 Apr 8;23(7):R270-2. doi: 10.1016/j.cub.2013.03.013.

Cell biology: Notch recycling is numbed.

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1
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria.

Abstract

During asymmetric cell division, the Notch regulator Numb segregates unequally to establish different cell fates in the two daughter cells. Numb is thought to act as an endocytic protein. Two new studies show that Numb antagonizes Notch signaling by also regulating recycling of Sanpodo-Notch complexes via AP-1.

PMID:
23578871
DOI:
10.1016/j.cub.2013.03.013
[Indexed for MEDLINE]
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