Format

Send to

Choose Destination
Trends Cell Biol. 2013 Aug;23(8):374-9. doi: 10.1016/j.tcb.2013.03.003. Epub 2013 Apr 9.

PTEN plasticity: how the taming of a lethal gene can go too far.

Author information

1
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Abstract

PTEN loss drives many cancers and recent genetic studies reveal that often PTEN is antagonised at the protein level without alteration of DNA or RNA expression. This scenario can already cause malignancy, because PTEN is haploinsufficient. We here review normally occurring mechanisms of PTEN protein regulation and discuss three processes where PTEN plasticity is needed: ischaemia, development, and wound healing. These situations demand transient PTEN suppression, whereas cancer exploits them for continuous proliferation and survival advantages. Therefore, increased understanding of PTEN plasticity may help us better interpret tumour development and ultimately lead to drug targets for PTEN supporting cancer therapy.

KEYWORDS:

PTEN regulation; nerve regeneration; stroke; tumour suppressor

PMID:
23578748
PMCID:
PMC3728179
DOI:
10.1016/j.tcb.2013.03.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center