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Med Res Rev. 2014 Jan;34(1):136-59. doi: 10.1002/med.21284. Epub 2013 Apr 10.

The PIM family of serine/threonine kinases in cancer.

Author information

1
Experimental Therapeutics Programme, Spanish National Cancer Research Centre, Madrid, Spain.

Abstract

The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that are highly evolutionarily conserved. These proteins are regulated primarily by transcription and stability through pathways that are controlled by Janus kinase/Signal transducer and activator of transcription, JAK/STAT, transcription factors. The PIM family proteins have been found to be overexpressed in hematological malignancies and solid tumors, and their roles in these tumors were confirmed in mouse tumor models. Furthermore, the PIM family proteins have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery. In the present work, we review the importance of PIM kinases in tumor growth and as drug targets.

KEYWORDS:

PIM kinases; cancer; oncogenes

PMID:
23576269
DOI:
10.1002/med.21284
[Indexed for MEDLINE]

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