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Am J Geriatr Psychiatry. 2013 May;21(5):493-6. doi: 10.1016/j.jagp.2013.01.014. Epub 2013 Feb 6.

Reduced serum nerve growth factor in patients with late-life depression.

Author information

1
Laboratory of Neuroscience (LIM-27), Department of Mental Health, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. brenosatler@gmail.com

Abstract

INTRODUCTION:

Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders.

METHODS:

We recruited 77 age- and gender-matched elderly subjects (38 with late-life depression, 17 with previous major depressive episode, and 22 healthy subjects in the comparison group). Serum concentration of NGF was determined by enzyme-linked immunosorbent assay.

RESULTS:

NGF levels were significantly reduced in the depressed patients (p = 0.002) as compared with healthy elderly controls. Elderly control subjects with previous depressive episode also showed a significant reduction in NGF levels as compared with controls (p <0.01); NGF levels were similar between patients with current depressive episode and previous depressive episode (p = 0.2).

CONCLUSION:

The present findings provide additional evidence to the relevance of reduced neurotrophic support in the pathophysiology of late-life depression. Also, reduced serum NGF level may be a state marker of depression in elderly subjects.

PMID:
23570892
DOI:
10.1016/j.jagp.2013.01.014
[Indexed for MEDLINE]

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