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Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):55-60. doi: 10.1016/j.oooo.2013.02.007. Epub 2013 Apr 6.

Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy.

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1
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the efficacy of radiation-based locoregional therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients who did not respond to induction chemotherapy (IC).

STUDY DESIGN:

Outcomes after radiation-based locoregional therapy were retrospectively analyzed.

RESULTS:

Among a total of 208 patients treated with IC, 46 (22.1%) did not respond. After IC, patients were treated with radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or surgery with or without postoperative RT. Among the 46 nonresponders, 17 (37.8%) patients underwent surgery and 28 (62.2%) were treated with RT or CCRT. Responses to subsequent RT or CCRT for 26 evaluable patients were as follows: complete response=7 (26.9%), partial response=9 (34.6%), stable disease=4 (15.4%), and progressive disease=6 (23.1%).

CONCLUSION:

A significant proportion of LA-HNSCC patients who did not respond to IC can benefit from subsequent RT or CCRT.

PMID:
23570665
DOI:
10.1016/j.oooo.2013.02.007
[Indexed for MEDLINE]
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