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BMC Psychiatry. 2013 Apr 9;13:110. doi: 10.1186/1471-244X-13-110.

Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies.

Author information

1
Department of Neuroscience, Uppsala University, Box 593, Husargatan 3, Uppsala, Sweden.

Abstract

BACKGROUND:

Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.

METHODS:

In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.

RESULTS:

Anorexia nervosa (AN) patients have global reductions in gray (effect size = -0.66) and white matter (effect size = -0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.

CONCLUSIONS:

Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.

PMID:
23570420
PMCID:
PMC3664070
DOI:
10.1186/1471-244X-13-110
[Indexed for MEDLINE]
Free PMC Article

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