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Asian Pac J Trop Biomed. 2012 Sep;2(9):727-32. doi: 10.1016/S2221-1691(12)60218-4.

Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.

Author information

1
Department of Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria ; Department of Biochemistry, Lagos State University, PMB 0001, Ojo, Lagos, Nigeria ; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

Abstract

OBJECTIVE:

To evaluate the antioxidant and antiglycation potential of polyphenols from three spices; alligator pepper, ginger and nutmeg.

METHODS:

Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay, phytotoxicity test, DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.

RESULTS:

Results obtained showed that polyphenol extract of ginger has the highest antioxidant potential with IC50 0.075 and 0.070 mg/mL for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC50 0.125 mg/mL. However, nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD50 4359.70 and 1490 µg/mL respectively.

CONCLUSIONS:

It can be concluded that the polyphenol extracts of alligator pepper, ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are safe for consumption.

KEYWORDS:

Antioxidants; Free radicals; Glycation; Hyperglycemia; Polyphenols; Spices

PMID:
23570003
PMCID:
PMC3609371
DOI:
10.1016/S2221-1691(12)60218-4
[Indexed for MEDLINE]
Free PMC Article

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