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Asian Pac J Trop Biomed. 2012 Jun;2(6):430-2. doi: 10.1016/S2221-1691(12)60070-7.

Antidiarrhoeal activity of leaf methanolic extract of Rauwolfia serpentina.

Author information

1
Department of Veterinary Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

Abstract

OBJECTIVE:

To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina (R. serpentina) in experimental diarrhoea induced by castor oil in mice.

METHODS:

Doses of 100, 200 and 400 mg/kg R. serpentina leaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal activity.

RESULTS:

All doses of the extract and the reference drug atropine sulphate (3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl (5 mg/kg, p.o.).

CONCLUSIONS:

The results show that the extract of R. serpentina leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.

KEYWORDS:

Antidiarrhoeal activity; Castor oil; Intestinal transit; Rauwolfia serpentina

PMID:
23569944
PMCID:
PMC3609332
DOI:
10.1016/S2221-1691(12)60070-7
[Indexed for MEDLINE]
Free PMC Article
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