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J Biomed Mater Res A. 2014 Jan;102(1):30-6. doi: 10.1002/jbm.a.34667. Epub 2013 Apr 9.

Osseointegration of atmospheric plasma-sprayed titanium implants: Influence of the native oxide layer.

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Research & Development in Physics, Materials and Nanostructures Laboratory, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre - RS, Brazil.


The aim of this study was to evaluate in vivo the influence of the native oxide layer on osseointegration and new bone formation on the surface of atmospheric plasma-sprayed porous titanium coatings. Porous titanium coatings were deposited on all implant surfaces, and half of the samples were subsequently submitted to oxide layer removal treatment. Samples were implanted onto the cortical bone of sheep (tibia) and evaluated at 30 and 60 days. Implants were removed en bloc and the attachment of bone to implants was examined by tensile pull-out test (osseointegration assessment), light microscopy, scanning electron microscopy (histological analysis), and instrumented hardness tests (mechanical properties of mature and newly formed bone tissue). Coatings submitted to oxide layer treatment presented higher osseointegration values at both healing periods and showed more mature and mineralized bone tissue when compared with nontreated coatings. Our findings showed that the use of acid-etching in association with atmospheric plasma spraying techniques improves osseointegration of titanium implants.


biomechanics; osseointegration; plasma spraying; surface modification; titanium oxide

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