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Mol Biosyst. 2013 Jun;9(6):1286-9. doi: 10.1039/c3mb70081j. Epub 2013 Apr 9.

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus.

Author information

1
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3LZ, Scotland, UK.

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.

PMID:
23567908
DOI:
10.1039/c3mb70081j
[Indexed for MEDLINE]

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