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Curr Opin Cell Biol. 2013 Jun;25(3):378-86. doi: 10.1016/ Epub 2013 Apr 6.

Nuclear pore complexes in the maintenance of genome integrity.

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Cardiovascular Research Institute, Biochemistry and Biophysics Department, University of California San Francisco, San Francisco, CA 94158, United States.


Maintaining genome integrity is crucial for successful organismal propagation and for cell and tissue homeostasis. Several processes contribute to safeguarding the genomic information of cells. These include accurate replication of genetic information, detection and repair of DNA damage, efficient segregation of chromosomes, protection of chromosome ends, and proper organization of genome architecture. Interestingly, recent evidence shows that nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, play important roles in these processes suggesting that these multiprotein platforms are key regulators of genome integrity.

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