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Mol Brain. 2013 Apr 8;6:15. doi: 10.1186/1756-6606-6-15.

Fragile X mental retardation protein and synaptic plasticity.

Author information

1
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 46-3301, USA.

Abstract

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.

PMID:
23566911
PMCID:
PMC3636002
DOI:
10.1186/1756-6606-6-15
[Indexed for MEDLINE]
Free PMC Article

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