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Bioorg Med Chem Lett. 2013 May 15;23(10):3001-6. doi: 10.1016/j.bmcl.2013.03.031. Epub 2013 Mar 21.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel.

Author information

1
DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@dupont.com

Abstract

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

PMID:
23566518
DOI:
10.1016/j.bmcl.2013.03.031
[Indexed for MEDLINE]
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