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Clin Exp Ophthalmol. 2013 Nov;41(8):753-60. doi: 10.1111/ceo.12111. Epub 2013 Apr 25.

Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma.

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1
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Abstract

BACKGROUND:

The result of primary open-angle glaucoma is the loss of retinal ganglion cells. Transient receptor potential cation channel 6 is a pressure-related channel that may function in the survival of retinal ganglion cells. The purpose of this study was to evaluate the expression levels of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma.

DESIGN:

Randomization study at Zhongshan Ophthalmic Center in China.

PARTICIPANTS:

80 primary open-angle glaucoma patients and 75 cataract patients recruited from Zhongshan Ophthalmic Center.

METHODS:

Total RNA was extracted from the leukocytes of the peripheral blood collected. The levels of transient receptor potential cation channel 6-messenger RNA were determined by real-time polymerase chain reaction. Related factors including age, intraocular pressure, optic cup-to-disc ratio and visual field defect were analysed accordingly.

MAIN OUTCOME MEASURES:

Clinical examination and the messenger RNA level.

RESULTS:

The expression level of the transient receptor potential cation channel 6 gene in the leukocytes of primary open-angle glaucoma patients was two times higher when compared with control cataract patients. The gene expression level was also correlated with intraocular pressure and cup-to-disc ratio. Treatment with different anti-glaucoma drugs did not affect the gene expression.

CONCLUSIONS:

Increasing expression levels of the transient receptor potential cation channel 6 gene in the blood accompanies chronic elevation of intraocular pressure in primary open-angle glaucoma and may serve as a genetic biomarker for primary open-angle glaucoma.

KEYWORDS:

TRPC6; intraocular pressure (IOP); primary open-angle glaucoma (POAG)

PMID:
23566105
DOI:
10.1111/ceo.12111
[Indexed for MEDLINE]
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