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Biosci Biotechnol Biochem. 2013;77(4):847-9. Epub 2013 Apr 7.

Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY.

Author information

1
Division of Systems Biology, Department of Innovative Science and Technology for Bio-industry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.

Abstract

We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

PMID:
23563534
DOI:
10.1271/bbb.120747
[Indexed for MEDLINE]
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