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Gene. 2013 Jun 10;522(1):37-45. doi: 10.1016/j.gene.2013.03.087. Epub 2013 Apr 2.

Unusual features in organisation of capsular polysaccharide-related genes of C. jejuni strain X.

Author information

1
School of Life Sciences, Kingston University, Faculty of Science, Engineering and Computing, Penrhyn Road, Kingston-upon Thames, KT1 2EE, UK. a.karlyshev@kingston.ac.uk

Abstract

PCR probing of the genome of Campylobacter jejuni strain X using conserved capsular polysaccharide (CPS)-related genes allowed elucidation of a complete sequence of the respective gene cluster (cps). This is the largest known Campylobacter cps cluster (38 kb excluding flanking kps regions), which includes a number of genes not detected in other Campylobacter strains. Sequence analysis suggests genetic rearrangements both within and outside the cps gene cluster, a mechanism which may be responsible for mosaic organisation of sugar transferase-related genes leading to structural variability of the capsular polysaccharide (CPS).

PMID:
23562723
DOI:
10.1016/j.gene.2013.03.087
[Indexed for MEDLINE]

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