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An Pediatr (Barc). 2014 Jan;80(1):47-50. doi: 10.1016/j.anpedi.2013.02.020. Epub 2013 Apr 3.

[Interpretation of the tuberculin test in children with CD4 lymphocyte cell mediated immunity changes].

[Article in Spanish]

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Servicio de Pediatría, Hospital Carlos III, Madrid, España. Electronic address:
Servicio de Pediatría, Hospital Carlos III, Madrid, España.


Immunosuppression could be a cause of a false negative tuberculin skin test (TST) result. A cross-sectional study was performed on a population of immigrants and internationally adopted children to analyse whether CD4 cell counts could modify the TST results. A total of 1074 children were included between January 2003 and December 2008. CD4 cell counts were performed on 884 children, in whom 5.3% had CD4 values <25%. There were no differences in TST results among children with normal and pathological CD4 cell counts. Several studies, including this one, have shown that there is no direct association between the CD4 value and the TST results. These results should be confirmed with larger series and with a higher percentage of children with CD4 values <25%.


CD4 cell counts; Children; Immunosuppression; Inmunodeprimidos; Linfocitos CD4; Niños; Prueba de tuberculina; Tuberculin test; Tuberculosis

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