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Planta Med. 1990 Feb;56(1):66-9.

In vitro activity of protoanemonin, an antifungal agent.

Author information

1
Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Spain.

Abstract

Protoanemonin, the lactone of gamma-hydroxy-vinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 micrograms/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg.

PMID:
2356244
[Indexed for MEDLINE]

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