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Planta Med. 1990 Feb;56(1):36-40.

Anti-inflammatory activity and sub-acute toxicity of artemetin.

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Department of Pharmacology, Universidade de São Paulo, Brasil.


The 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 The doses of 102.6 and 153.9 showed an inhibitory effect similar to that of 50.0 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 Repeated administration of artemetin at doses of 67.07 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.

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