Format

Send to

Choose Destination
See comment in PubMed Commons below
Schizophr Res. 2013 Jun;147(1):53-57. doi: 10.1016/j.schres.2013.02.038. Epub 2013 Apr 2.

Endocannabinoid metabolism in the prefrontal cortex in schizophrenia.

Author information

1
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address: volkdw@upmc.edu.
2
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States.
3
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, United States.
4
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States.

Abstract

Adolescent cannabis use is associated with greater relative risk, increased symptom severity, and earlier age of onset of schizophrenia. We investigated whether this interaction may be partly attributable to disease-related disturbances in metabolism of the major cortical endocannabinoid 2-arachidonoylglycerol (2-AG). Transcript levels for the recently discovered 2-AG metabolizing enzyme, α-β-hydrolase domain 6 (ABHD6), were assessed using quantitative PCR in the prefrontal cortex of schizophrenia and healthy subjects (n=84) and antipsychotic- or tetrahydrocannabinol-exposed monkeys. ABHD6 mRNA levels were elevated in schizophrenia subjects who were younger and had a shorter illness duration but not in antipsychotic- or tetrahydrocannabinol-exposed monkeys. Higher ABHD6 mRNA levels may increase 2-AG metabolism which may influence susceptibility to cannabis in the earlier stages of schizophrenia.

PMID:
23561296
PMCID:
PMC3650113
DOI:
10.1016/j.schres.2013.02.038
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center