Abstract
Niwa and colleagues report in this issue that treatment with the DNA demethylation agent 5-aza-2'-deoxycytidine decreases the incidence of gastric cancers in an animal model of Helicobacter pylori-promoted gastric cancer. This provocative study underscores the importance of changes in DNA methylation that contribute to the origin of inflammation-related cancers. The findings also raise the exciting possibility of cancer prevention by altering DNA methylation events early during tumorigenesis.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Adenocarcinoma / microbiology*
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Adenocarcinoma / prevention & control*
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Animals
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Azacitidine / analogs & derivatives*
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Azacitidine / therapeutic use
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DNA-Cytosine Methylases / antagonists & inhibitors*
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Decitabine
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Helicobacter Infections / complications*
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Helicobacter pylori / physiology*
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Male
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Stomach Neoplasms / microbiology*
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Stomach Neoplasms / prevention & control*
Substances
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Decitabine
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DNA-Cytosine Methylases
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Azacitidine