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Exerc Sport Sci Rev. 2013 Jul;41(3):162-8. doi: 10.1097/JES.0b013e3182948a1e.

The role of Nrf2 in the attenuation of cardiovascular disease.

Author information

1
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA. nellie.reuland@colostate.edu

Abstract

Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.

PMID:
23558695
DOI:
10.1097/JES.0b013e3182948a1e
[Indexed for MEDLINE]

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