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Magn Reson Med. 1990 Jun;14(3):538-46.

Functional cerebral imaging by susceptibility-contrast NMR.

Author information

1
Department of Radiology, Massachusetts General Hospital, Boston.

Abstract

In vivo measurement of cerebral physiology by dynamic contrast-enhanced NMR is demonstrated. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility-induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured.

PMID:
2355835
DOI:
10.1002/mrm.1910140311
[Indexed for MEDLINE]

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