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Neuroscience. 2013 Jul 23;243:46-53. doi: 10.1016/j.neuroscience.2013.03.039. Epub 2013 Apr 1.

Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice.

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Departamento de Farmacologia, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.


L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.

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