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Biomarkers. 2013 May;18(3):196-203. doi: 10.3109/1354750X.2012.762805. Epub 2013 Apr 5.

Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.

Author information

1
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. eco7@columbia.edu

Abstract

CONTEXT:

Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.

OBJECTIVE:

Test associations of endothelial biomarkers with FEV1 using instrumental variables.

METHODS:

Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.

RESULTS:

ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.

CONCLUSION:

Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

PMID:
23557128
PMCID:
PMC3890095
DOI:
10.3109/1354750X.2012.762805
[Indexed for MEDLINE]
Free PMC Article

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