Format

Send to

Choose Destination
PLoS One. 2013;8(3):e59701. doi: 10.1371/journal.pone.0059701. Epub 2013 Mar 26.

Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America. jacarrer@wustl.edu

Erratum in

  • PLoS One. 2014;9(1). doi:10.1371/annotation/f277b29e-361b-4e56-b55b-612ebaca0432.

Abstract

Our ability to successfully intervene in disease processes is dependent on definitive diagnosis. In the case of autoimmune disease, this is particularly challenging because progression of disease is lengthy and multifactorial. Here we show the first chronological compendium of transcriptional and cellular signatures of diabetes in the non-obese diabetic mouse. Our data relates the immunological environment of the islets of Langerhans with the transcriptional profile at discrete times. Based on these data, we have parsed diabetes into several discrete phases. First, there is a type I interferon signature that precedes T cell activation. Second, there is synchronous infiltration of all immunological cellular subsets and a period of control. Finally, there is the killing phase of the diabetogenic process that is correlated with an NF-kB signature. Our data provides a framework for future examination of autoimmune diabetes and its disease progression markers.

PMID:
23555752
PMCID:
PMC3608568
DOI:
10.1371/journal.pone.0059701
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center