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PLoS One. 2013;8(3):e59256. doi: 10.1371/journal.pone.0059256. Epub 2013 Mar 12.

Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population.

Author information

1
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Abstract

BACKGROUND:

A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population.

METHODS:

We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations.

RESULTS:

No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84-1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80-1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82-1.13, P = 0.621 for rectum cancer).

CONCLUSIONS:

Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population.

PMID:
23555006
PMCID:
PMC3595231
DOI:
10.1371/journal.pone.0059256
[Indexed for MEDLINE]
Free PMC Article

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