Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Biochem. 2013 Sep;114(9):2039-49. doi: 10.1002/jcb.24545.

AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells.

Author information

1
Department of Oral and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Abstract

In this study, we found that wounding of a confluent monolayer of squamous cell carcinoma (SCC) cells induced epithelial-mesenchymal transition (EMT) specifically at the edge of the wound. This process required the combined stimulation of TGFβ, TNFα, and PDGF-D. Such a combined cytokine treatment of confluent monolayers of the cells upregulated the expression levels of Snail and Slug via PI3K. The PI3K downstream effector, AKT, was dispensable for the upregulation of Snail and Slug, but essential for enabling EMT in response to upregulation of Snail and Slug.

KEYWORDS:

AKT; EMT; PI3K; SNAIL; SQUAMOUS CELL CARCINOMA

PMID:
23553960
DOI:
10.1002/jcb.24545
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center