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Pharmacotherapy. 2013 Jul;33(7):710-7. doi: 10.1002/phar.1262. Epub 2013 Apr 1.

Lack of effectiveness of sodium bicarbonate in preventing kidney injury in patients undergoing cardiac surgery: a randomized controlled trial.

Author information

1
Department of Pharmacy Practice, School of Pharmacy, Wilkes University, Wilkes-Barre, Pennsylvania 18766, USA. Judith.kristeller@wilkes.edu

Abstract

STUDY OBJECTIVE:

Because alkalinization of the renal tubules can theoretically protect against the mechanisms of acute kidney injury, we sought to determine whether a sodium bicarbonate infusion can prevent acute kidney injury after cardiac surgery.

DESIGN:

Prospective, randomized, double-blind, controlled trial.

SETTING:

Cardiac surgery service in a community hospital.

PATIENTS:

Ninety-two patients with stage 3 or higher chronic kidney disease who underwent cardiac surgery using cardiopulmonary bypass.

INTERVENTION:

Forty-eight patients received a perioperative intravenous infusion of 0.9% sodium chloride 154 mEq/L, and 44 patients received an infusion of sodium bicarbonate infusion 150 mEq/L in 5% dextrose solution; the infusions were started 1 hour preoperatively and continued for 6 hours after cardiopulmonary bypass.

MEASUREMENTS AND MAIN RESULTS:

The primary outcome was the development of any stage of acute kidney injury within 5 days after surgery as defined by the Acute Kidney Injury Network criteria. No statistically significant difference in the primary outcome was noted between the two groups: 32% in the bicarbonate group versus 42% in the sodium chloride group (p=0.12). Likewise, no significant differences in the 30-day hospital mortality rate or other adverse outcomes were noted between the two groups.

CONCLUSION:

A perioperative infusion of sodium bicarbonate did not reduce the rate of acute kidney injury or adverse outcomes in patients with chronic kidney disease who underwent cardiac surgery.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00921518.

KEYWORDS:

cardiopulmonary bypass; kidney injury; sodium bicarbonate

PMID:
23553549
DOI:
10.1002/phar.1262
[Indexed for MEDLINE]
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