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Cell Biochem Biophys. 2013;67(3):1029-32. doi: 10.1007/s12013-013-9600-1.

A resting-state functional magnetic resonance imaging study of acute carbon monoxide poisoning in humans.

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Department of Neurology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, 214400, Jiangsu, China,


The objective of this study was to evaluate the brain function characteristics of carbon monoxide poisoning patients using resting-state functional magnetic resonance imaging (fMRI) method. For this purpose, 12 carbon monoxide poisoning patients and healthy controls were subjected to resting-state fMRI scans separately. A regional homogeneity (ReHo) approach was used to analyze the brain function in carbon monoxide poisoning patients. Compared with control group, the value of ReHo in carbon monoxide poisoning group showed distinct decrease in bilateral superior frontal gyrus, middle frontal gyrus, right cuneus, left middle temporal gyrus, right insula, and cerebellum. Therefore, it was concluded that the brain functions in carbon monoxide poisoning patients were abnormal under the resting-state. The cuneate lobe function may indicate the degree of brain hypoxia and strengthening the cerebellar function training may promote the rehabilitation process.

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