Format

Send to

Choose Destination
Folia Neuropathol. 2013;51(1):1-9.

Molecular mechanisms of neuropathological changes in Alzheimer's disease: a review.

Author information

1
Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic. omarsery@sci.muni.cz

Abstract

More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.

PMID:
23553131
DOI:
10.5114/fn.2013.34190
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Termedia Publishing House Ltd.
Loading ...
Support Center